WOW! New Research on PEA Changes Everything!

PEA Superehero Molecule

Recommended product: The new “PEA Healthy Inflammation Response with Serratiopeptidase.”

Got widespread discomfort, brain fog, fatigue and insomnia? Also have sensitivities? Been wondering what ties all these disparate symptoms together?

We now have an answer…

Past research pointed to two key processes contributing to these:

Activation of sensitivity triggering mast cells
Activation of brain regulating cells called microglia

It is common to see both activating together, wreaking havoc in your body. But we did not know why both are triggered.

Research is now showing why and offering a solution to both. And it’s helping people feel sooo much better!

During times of severe stress and distress, certain cells in our bodies make a “superhero molecule” called PEA (Palmitoylethanolamide) to come to the rescue. The missing link? Both the mast and microglial cells are two key cells that produce PEA. So, they get activated trying to produce more and stay activated when they can’t produce enough.

Excess activation of these cells causes everything I noted above, with both directly suppressing the hypothalamus when overactive.

What to Do?

It takes about 2-3 months, but supplying the PEA can settle down these cells, along with the sensitivities, pain, fatigue, increased appetite, weight, etc. Improvements then continue to increase over time.

It can give people their lives back.

The problem? PEA is very difficult for the body to absorb. Fortunately, a new natural compound called Gammasorb can dramatically help this, making the PEA even more effective. I use this form in my practice, which is also combined with inflammation dissolving Serratiopeptidase. It is available in a product called “PEA Healthy Inflammation Response with Serratiopeptidase” by EuroPharma.

In yet another study and an accompanying three minute video, prominent Netherlands pain specialist Prof Jan Keppel Hesselink (I recommend you watch the video;-) shares his experience using PEA in many thousands of people with severe chronic pain.

The research shows dramatic drops in pain of 60-70%, (the VAS pain scale dropped from 7.1 to 2.2!) where a 30% drop is clinically quite significant. The initial studies compared a dose of 300 versus 600 mg a day of PEA. The 600 mg dose was much more effective than the lower dose.

Since then, he has explored and fine tuned his recommended PEA dosing, and found that higher dosing appears to result in quicker and more powerful responses.

Here is the dosing Prof Jan Keppel Hesselink recommends:

He starts with PEA 600 mg twice a day in chronic discomfort, gives it a month, and then increases to 1,200 mg twice a day for two months as a fair therapeutic trial.
Most often, he is seeing pain relief beginning at three weeks using this higher dosing.

Many, if not most, PEA products recommend a 600 mg dose, which typically requires two capsules.

Once you see what works best for you, you can adjust the PEA to that dose. As symptoms stay settled for three months, dosing can likely be significantly lowered and still maintain the benefits.

This is very exciting new stuff. Please email me at FatigueDoc@gmail.com and let me know your experience with it.

Want to see what numerous other studies are showing?

PEA: The Missing Link

Frankly, having a form of PEA that is highly absorbed changes everything. (Note: Be careful when choosing a PEA source. The letters "PEA" are used for many molecules, and you need the one for the molecule Palmitoylethanolamide.)

It makes the dozens of studies meaningful in helping people.

Optional Reading for Those Who Want to See the Science

So let’s look at just some of these studies, so you can get a sense of why I am so excited.

Let’s start with a review article that has over 212 study references. The review discusses how PEA also works through cannabinoid systems as well as PPAR pathways. Basically this means it is working by mechanisms we don’t have good medications for.

And it works to help so many things. As the review notes. PEA “provide[s] therapeutic benefits in many applications, including immunity, brain health, allergy, pain modulation, joint health, sleep and recovery. PEA’s poor oral bioavailability, a major obstacle in early research, has been overcome by advanced delivery systems.”

“PEA is thought to be produced as a protective response to cellular injury … effects include… analgesic, anticonvulsant, antimicrobial, … immunomodulatory and neuroprotective activities [14,17,21,22,23]. PEA’s multi-faceted effects are due to its unique mechanisms of action.” It also helps your immune system with viruses, bacteria, and “leaky gut.”

“PEA’s neuroprotective effects are due to its ability to modify microglia and astrocyte activation.” As an added bonus it even improves mood.

PEA also powerfully decreases discomfort by over a dozen different mechanisms, including addressing central sensitization. It supplies an alternative for those who can’t get or use low dose naltrexone, and can be synergistic with LDN as well.

Another study showed PEA significantly improved recovery from exercise, so it may be helpful for PEM.

The PEA may improve sleep. “PEA’s combined analgesic, anxiolytic and [mood lifting] effects differentiate it from any other sleep aid currently in use, and make it an attractive alternative to current treatments.”

As an aside, chronic discomfort is associated with more rapid brain aging (see study PDF)..

As I’ve noted in earlier articles, I suspect this is largely through mechanisms such as microglial activation. PEA can markedly help this, and research has shown it to be brain protective. This brain protective quality is discussed in a review with over 100 references. It even enhances neurogenesis (growth of new healthy brain cells), and can help the brain in a large number of conditions.

Making it an important “ounce of prevention” as well to protect brain health, the PEA also helped improve cognitive function — even in healthy people.

Another meta-analysis looked at 253 studies on PEA for discomfort, of which 11 were included in the meta-analysis. The conclusion? “PEA is an effective and well-tolerated treatment for chronic [discomfort].”

PEA and Microglial Activation, Mast Cell Activation and Histamine Release

Cellular studies show that PEA significantly helps settle down microglial activation as well as mast cells.

“Nowadays the efficacy of palmitoylethanolamide in controlling mast cell behaviour, which likely accounts for its many anti-inflammatory, anti-angiogenic and analgesic effects, is well recognized” (see study).

It also blocks histamine release by mast cells. Which is important.

Excess mast cell histamine release in the hypothalamus makes it very difficult to sleep. It can also contribute to discomfort, digestive and other symptoms (see study).

Tired, Achy, Brain Fog, and Can’t Sleep?

A number of studies have now shown PEA can improve these symptoms (study 1, study 2).

My recommendation for everyone with these symptoms? Get three bottles of the new “PEA Healthy Inflammation Response with Serratiopeptidase” (containing Gammasorb).

Use the dosing above. As with anything, if you have sensitivities start with a low dose (one quarter to one capsule a day) to make sure your body is okay with it and give it time to adapt if needed. Then you can raise the dose as quickly as your body is comfortable doing so. In a few cases it may be energizing enough to disrupt sleep. If this happens initially simply lower the dose, work up to higher doses, and take it in the morning.